ARID1A: guardian of normal pancreatic ducts

Aquaporins in rat pancreatic interlobular ducts.

The aquaporin (AQP) family of water channels is distributed ubiquitously in many epithelia and plays a fundamental role in transmembrane water transport. The aim of this study is to identify the water transport pathway in pancreatic duct cells where most of the HCO-rich fluid originates. Using digital videomicroscopy, we measured the osmotic water permeability (P(f)) of pancreatic duct epitheli...

Bicarbonate transport in microperfused pancreatic ducts.

Pancreatic endoscopic ultrasound-assisted rendezvous procedure to facilitate drainage of nondilated pancreatic ducts.

scopic ultrasound−assisted rendezvous procedures has been reported previously in patients with obstructive chronic pan− creatitis [1 ± 5]. However, there have been no reports describing the use of this tech− nique in patients with normal pancreatic duct dimensions. We present two patients, a 42−year−old woman with a history of recurrent acute pancreatitis and a tight, inaccessible pan− creatic ...

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis.

Ductal occlusion has been postulated to precipitate focal pancreatic inflammation, while the nature of the primary occluding agents has remained elusive. Neutrophils make use of histone citrullination by peptidyl arginine deiminase-4 (PADI4) in contact to particulate agents to extrude decondensed chromatin as neutrophil extracellular traps (NETs). In high cellular density, NETs form macroscopic...

Squamoid cyst of pancreatic ducts: a challenging differential diagnosis among benign pancreatic cysts.

CONTEXT In the last years, cystic pancreatic lesions are often detected when clinically silent, because of the wider use of diagnostic imaging techniques. First described by Othman in 2007, "squamoid cyst of pancreatic ducts" represents a cystic dilation of ducts, lined by non-keratinized squamous epithelium. We report the first case of squamoid cyst of pancreatic ducts in Italy. CASE REPORT ...